Intermittent fasting

In addition to weight loss after four weeks, intermittent fasting also had a positive effect on many health indicators, such as cholesterol, blood pressure, abdominal fat and inflammatory parameters. Photo: Artemtation/Pixabay.com.

Researchers at Graz find positive health effects

In the Interfast study, scientists from the University of Graz and the Medical University of Graz are jointly investigating the effects of intermittent fasting – more precisely, “alternate-day fasting” – a method in which you alternate between not eating anything for a day and eating everything for an unlimited period the next day. The first results have been published in the renowned journal Cell Metabolism. In addition to weight loss after four weeks, intermittent fasting also had a positive effect on many health indicators, such as cholesterol, blood pressure, abdominal fat and inflammatory parameters.

Sixty healthy volunteers in the Interfast project were divided into two groups. One group practised intermittent fasting for four weeks, and the other maintained their current lifestyle. “The study was supplemented by an additional 30 subjects who had already been practising alternate-day fasting for more than six months”, explain study directors Frank Madeo from the University of Graz and Thomas Pieber and Harald Sourij from the Medical University of Graz. “This made it possible for us to take a first, unique look at the long-term effects of alternate-day fasting.” The researchers wanted to investigate the effects of intermittent fasting on both body weight and molecular mechanisms in healthy subjects. The strict observance of the fasting days was closely monitored by means of continuous glucose measurement.

The results of the study were clear. “Within four weeks, the study participants had already reduced their body weight by an average of around 3.5 kilograms, with the average initial weight being 76 kilograms,” reports Thomas Pieber. The researchers saw not only a clear weight reduction among the fasting participants; they also registered an increase in ketones. “These are produced as a by-product of fat burning in carbohydrate deficiency and are suspected to have anti-ageing effects. Furthermore, in the fasting cohort, we saw a reduction of specific amino acid levels, cholesterol, systolic blood pressure, abdominal fat and inflammation parameters. Reductions in all these effects are associated with positive health impacts”, Frank Madeo says regarding the insights gained into molecular mechanisms. In addition, the researchers found a mild reduction of the thyroid hormone T3 in the fasting patients and a simultaneous increase in the thyroid-stimulating hormone TSH. This has already been associated with longevity in numerous studies.

“Intermittent fasting is a very simple but extremely effective dietary principle,” says Harald Sourij, who is looking forward to future research projects. The Interfast-2 study will begin building on the current results in autumn. It will investigate intermittent fasting in patients with type 2 diabetes who already require insulin therapy.

Publication: Stekovic, Hofer, and Tripolt et al. “Alternate day fasting improves physiological and molecular markers of aging in healthy, non-obese humans”, Cell Metabolism, DOI: 10.1016/j.cmet.2019.07.016

https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30429-2

Gerhild Leljak

Related news

Jurassic Sounds: Biologist reconstructs insect songs from 165 million years ago

It was apparently not just the roars of the dinosaurs that made up the soundscape of the animal world during the Jurassic period. Crickets and grasshoppers communicated through a variety of songs and high-pitched sounds, as Thorin Jonsson from the Institute of Biology at the University of Graz discovered together with colleagues from the universities of Lincoln, Bristol (UK), Beijing (China) and Tempe (USA). The findings on what are so far the oldest traces of sound on Earth have just been published in the journal PNAS.

EU funding boosts international exchange between universities

The University of Graz is further expanding its international study opportunities through the European university alliance Arqus and is taking the lead in two key projects. In future, students will benefit from even more joint degree programmes and from simplified recognition of academic achievements through the Joint European Degree Label.

Rescue and risks: Researchers have surveyed public perceptions of AI

The use of artificial intelligence has had to be made transparent since 2 August 2026. The EU’s AI Act, which has been in force since then, also sets out how risky an application is and which security measures apply as a result. However, the assessment of risks by the legislation differs in some cases significantly from the perceptions of the Austrian public. This is the finding of a representative study carried out by data scientist Stefan Thalmann from the University of Graz and his team.

The Healing Sea: Researchers discover new approaches to treating chronic inflammation in sponges

Chronic inflammation plays a key role in many diseases, ranging from metabolic disorders and cardiovascular diseases to tissue damage following injuries or infections. “Normally, the body is able to resolve inflammation on its own. If this process becomes unbalanced, immune cells remain permanently active and continue to drive negative changes in the tissue,” explains Andreas Koeberle, a pharmacist at the University of Graz.