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University of Graz News Alarm im Darm

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Wednesday, 19 June 2019

Alarm im Darm

Katrin Unterhauser erhielt den Preis von Herbert Tilg, Präsident der ÖGGH und Direktor der Univ.-Klinik Innere Medizin I in Innsbruck. Foto: ÖGGH/Birgit Pichler.

Katrin Unterhauser erhielt den Preis von Herbert Tilg, Präsident der ÖGGH und Direktor der Univ.-Klinik Innere Medizin I in Innsbruck. Foto: ÖGGH/Birgit Pichler.

Molekularbiologin Katrin Unterhauser erhielt den Friedrich Wewalka Gedächtnispreis

Das Darmbakterium Klebsiella oxytoca kann zu einem Problem werden – nämlich dann, wenn die natürliche Darmflora gestört ist, zum Beispiel durch die Einnahme von Antibiotika. Die Arbeitsgruppe von Ellen Zechner am Institut für Molekulare Biowissenschaften der Universität Graz hat Anfang des Jahres entdeckt, dass Klebsiella oxytoca in dem Fall zwei unterschiedliche, giftige Substanzen produziert, die beide dazu führen, dass es zu einer schweren Entzündung des Darms kommen kann. >> Mehr dazu

Federführend beteiligt an dieser Entdeckung war Katrin Unterhauser, die ihre Dissertation in Rahmen des Doktoratskollegs Molekulare Enzymologie an der Universität Graz im März 2019 erfolgreich abgeschlossen hatte. Das nächste Erfolgserlebnis für die junge Molekularbiologin: der Friedrich Wewalka Gedächtnispreis, der ihr vergangene Woche von der Österreichische Gesellschaft für Gastroenterologie und Hepatologie (ÖGGH) im Rahmen ihrer Jahrestagung in Innsbruck verliehen wurde.

Unterhausers eingereichte Arbeit mit dem Titel „Klebsiella oxytoca enterotoxins tilimycin and tilivalline have distinct host DNA damaging and microtubule stabilizing activities“ erschien vor Kurzem in der renommierten amerikanischen Fachzeitschrift „Proceedings of the National Academy of Sciences of the United States of America“ und wurde auf Basis der Reihung von externen GutachterInnen vom Vorstand der ÖGGH für den Friedrich Wewalka Preis ausgewählt. Dieser ist mit 8.000 Euro dotiert.
 

created by Gerhild Leljak

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It was apparently not just the roars of the dinosaurs that made up the soundscape of the animal world during the Jurassic period. Crickets and grasshoppers communicated through a variety of songs and high-pitched sounds, as Thorin Jonsson from the Institute of Biology at the University of Graz discovered together with colleagues from the universities of Lincoln, Bristol (UK), Beijing (China) and Tempe (USA). The findings on what are so far the oldest traces of sound on Earth have just been published in the journal PNAS.

EU funding boosts international exchange between universities

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Rescue and risks: Researchers have surveyed public perceptions of AI

The use of artificial intelligence has had to be made transparent since 2 August 2026. The EU’s AI Act, which has been in force since then, also sets out how risky an application is and which security measures apply as a result. However, the assessment of risks by the legislation differs in some cases significantly from the perceptions of the Austrian public. This is the finding of a representative study carried out by data scientist Stefan Thalmann from the University of Graz and his team.

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Chronic inflammation plays a key role in many diseases, ranging from metabolic disorders and cardiovascular diseases to tissue damage following injuries or infections. “Normally, the body is able to resolve inflammation on its own. If this process becomes unbalanced, immune cells remain permanently active and continue to drive negative changes in the tissue,” explains Andreas Koeberle, a pharmacist at the University of Graz.

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