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Original Research Articles
Color Code: Full Paper/ Note / Communication
2012
228. Microwave-assisted Continuous Flow Synthesis on Industrial Scale.
R. Morschhäuser, M. Krull, C. Kayser,
C. Boberski, R. Bierbaum, P. A. Püschner,
T. N. Glasnov, C. O. Kappe,
Green Process. Synthesis 2012, 1, in press.
227. High-Speed Microwave-assisted Synthesis of SEA0400 – a Selective Inhibitor of the Na+/Ca2+ Exchanger.
G. Guedes de la Cruz, K. Groschner, C. O. Kappe, T. N. Glasnov
Tetrahedron Lett. 2012, 53, in press.
226. Copper-Catalyzed C-O Bond Formation by Direct alpha-C-H Bond Activation of Ethers Using Stoichiometric Amounts of Peroxide in Batch and Continuous Flow Formats.
G. S. Kumar, B. Pieber, K. R. Reddy, C. O. Kappe,
Chem. Eur. J. 2012, 18, in press.
225. Treatment of Aqueous Waxy Corn Starch Dispersions in a Dedicated Microwave Reactor and
their Hydrodynamic Properties Determined Using Asymmetrical Flow Field-Flow Fractionation.
S. Juna, A. Huber, M. Damm, C. O. Kappe,
Starch 2012, in press.
224. Flash Flow Pyrolysis: Mimicking Flash Vacuum Pyrolysis in a High-Temperature/High-Pressure Liquid-Phase Microreactor Environment.
D. Cantillo, H. Sheibani, C. O. Kappe,
J. Org. Chem. 2012, 77, 2463-2473.
223. Safe Generation and Synthetic Utilization of Hydrazoic Acid in a Continuous Flow Reactor
B. Gutmann, J.-P. Roduit, D. Roberge, C. O. Kappe,
J. Flow Chem. 2012, 2,8-19.
222. A Critical Assessment of the Specific Role of Microwave Irradiation in the Synthesis of ZnO Micro- and Nano-structured Materials
M. Baghbanzadeh, S. D. Škapin, Z. C. Orel, C. O. Kappe,
Chem. Eur. J. 2012, 18, 5724-5731.
221. Direct Arylation of Benzene with Aryl Bromides Using High-Temperature/High-Pressure Process Windows – Expanding the Scope of C-H Activation Chemistry
B. Pieber, D. Cantillo, C. O. Kappe,
Chem. Eur. J. 2012, 18, 5047-5055.
220. Characterization of Microwave-induced Electric Discharge Phenomena in Metal-Solvent Mixture.
W. Chen, B. Gutmann, C. O. Kappe,
ChemistryOpen 2012, 1, 39-48.
219. High-Temperature Continuous Flow Synthesis of 1,3,4-Oxadiazoles via N-Acylation of 5-Substituted Tetrazoles.
B. Reichart, C. O. Kappe,
Tetrahedron Lett. 2012, 53, 952-955.
218. A Critical Investigation on the Microwave-Assisted Preparation of Supported Iron Oxide Nanoparticles on Silica-type Mesoporous Materials.
A. M. Balu, D. Dallinger, D. Obermayer, J. M. Campelo, A. A. Romero, D. Carmona, F. Balas, J. Santamaria, K. Yohida, P. L. Gai, C. Vargas, C. O. Kappe, R. Luque,
Green Chem. 2012, 14, 393-402.
2011
217. A Two-Step Continuous Flow Synthesis of N-(2-Aminoethyl)acylamides via Ring-Opening/Hydrogenation of Oxazolines.
B. Gutmann, J.-P. Roduit, D. Roberge, C. O. Kappe,
Chem. Eur. J. 2011, 17, 13146–13150.
216. A High-Throughput Platform for Low-Volume High-Temperature/Pressure Sealed Vessel Solvent Extractions.
M. Damm, C. O. Kappe,
Anal. Chim. Acta 2011, 707, 76-83.
215. Palladium-Catalyzed Direct Arylation of Heteroaromatic Compounds: Improved Conditions Utilizing Controlled Microwave Heating.
M. Baghbanzadeh, C. Pilger, C. O. Kappe,
J. Org. Chem. 2011, 76, 8138-8142.
214. Microwave-assisted Grafting to MCM-41 Silica
and its Application as Catalyst in Flow Chemistry.
M. Oliverio, A. Procopio, T. N. Glasnov, W. Goessler, C. O. Kappe,
Aust. J. Chem. 2011, 64, 1522-1529.
213. Microwave-assisted Forced Degradation Using High-Throughput Microtiter Platforms.
B. Prekodravac, M. Damm, C. O. Kappe,
J. Pham. Biomed. Anal. 2011, 53, 867-873.
212. Microwave-Assisted and Continuous Flow Multistep Synthesis of 4-(Pyrazol-1-yl)carboxanilides.
D. Obermayer, T. N. Glasnov, C. O. Kappe,
J. Org. Chem. 2011, 76, 6657-6669.
211. Scale-Up of Microwave-assisted Reactions in a Multimode Bench-top Reactor.
D. Dallinger, H. Lehmann, J. D. Moseley, A. Stadler, C. O. Kappe,
Org. Process Res. Develop. 2011, 15, 841-854.
210. A Scalable Two-Step Continuous Flow Synthesis of Nabumetone and Related 4-Aryl-2-butanones.
M. Viviano, T. N. Glasnov, B. Reichart, G. Tekautz, C. O. Kappe
Org. Process Res. Develop. 2011, 15, 858-870.
209. Engineering of the TRPC3 Selectivity Filter Reveals a Dichotomic, TRPC-mediated
Signaling Gateway in Cardiac Excitation-transcription Coupling.
M. Poteser, H. Schleifer, M. Lichtenegger, M. Schernthaner,
T. Stockner, C. O. Kappe, T. N. Glasnov, C. Romanin, K. Groschner,
Proc. Nat. Acad. Sci. USA 2011, 108, 10556-10561.
208. Activation and Deactivation of a Chemical Transformation by an Electromagnetic Field – Evidence for Specific Microwave Effects in the Formation of Grignard Reagents.
B. Gutmann, A. M. Schwan, B. Reichart, C. Gspan, F. Hofer, C. O. Kappe,
Angew. Chem. Int. Ed. 2011, 50, 7636-7640.
207. Pentafluorophenyl-bis(diethylamino)phosphane - A Push-Pull Phosphane Available for Coordination.
A. Orthaber, M. Fuchs, F. Belaj, G. N. Rechberger, C. O. Kappe, R. Pietschnig,
Eur. J. Inorg. Chem. 2011, 2588-2596.
206. Unusual Behavior in the Reactivity of 5-Substituted-1H-tetrazoles in a Resistance-Heated Microreactor.
B. Gutmann, T. N. Glasnov, T. Razzaq, W. Goessler, D. M. Roberge, C. O. Kappe,
Beilstein. J. Org. Chem. 2011, 7, 503-717.
205. Mechanistic Insights on Azide-Nitrile Cycloadditions: On the Dialkyltin Oxide-Trimethylsilyl Azide Route and a New Vilsmeier-Haack-Type Organocatalyst.
D. Cantillo, B. Gutmann, C. O. Kappe,
J. Am. Chem. Soc. 2011, 133, 4465-4475.
204. Microwave-Assisted Nickel(II) Acetylacetonate-Catalyzed Arylation of Aldehydes with Arylboronic Acids.
W. Chen, M. Baghbanzadeh, C. O. Kappe,
Tetrahedron Lett. 2011, 52, 1677-1679.
203. Continuous Flow Ozonolysis in a Laboratory Scale Reactor.
M. Irfan, T. N. Glasnov, C. O. Kappe,
Org. Lett. 2011, 14, 984-987.
202. Rapid Nickel-Catalyzed Suzuki- Miyaura Cross-Couplings of Aryl Carbamates and Sulfamates Utilizing Microwave Heating.
M. Baghbanzadeh, C. Pilger, C. O. Kappe,
J. Org. Chem. 2011, 76, 1507-1510.
201. A Miniaturized Microtiter Plate Protocol for the Determination of Selenomethionine in Selenized Yeast via Enzymatic Hydrolysis of Protein-bound Selenium.
M. Stiboller, M. Damm, A. M. Barbera, D. Kuehnelt, K. A. Francesconi, C. O. Kappe,
Anal. Meth. 2011, 3, 738-741.
200. Investigation of the Formation of CuInS2 Nanoparticles by the Oleylamine Route – Comparison of Microwave-Assisted with Conventional Syntheses.
A. Pein, M. Baghbanzadeh, T. Rath, W. Haas, E. Maier, H. Amenitsch, F. Hofer, C. O. Kappe, G. Trimmel,
Inorg. Chem. 2011, 50, 193-200.
2010
199. A Unified Mechanistic View on the Morita-Baylis-Hillman Reaction: Computational and Experimental Investigations.
D. Cantillo, C. O. Kappe,
J. Org. Chem. 2010, 75, 8615-8626.
198. Microwave-Assisted High-Throughput Acid Hydrolysis in Silicon Carbide Microtiter Platforms - A Rapid and Low Volume Sample Preparation Technique for Total Amino Acid Analysis in Proteins and Peptides.
M. Damm, M. Holzer, G. Radspieler, G. Marsche, C. O. Kappe,
J. Chromat. A. 2010, 1217, 7826-7832.
197. Toward a Continuous Flow Synthesis of Boscalid.
T. N. Glasnov, C. O. Kappe
Adv. Synth. Catal. 2010, 352, 3089-3097.
196. Structure-Activity Relationships and Molecular Docking of Novel Dihydropyrimidine-Based Mitotic Eg5 Inhibitors.
H. Prokopcová, D. Dallinger, G. Uray, H. Y. K. Kaan, V. Ulaganathan, F. Kozielski, C. Laggner, C. O. Kappe,
ChemMedChem 2010, 5, 1760-1769.
195. Sintered Silicon Carbide: A New Ceramic Vessel Material for Microwave Chemistry in Single-Mode Reactors.
B. Gutmann, D. Obermayer, B. Reichart, B. Prekodravac, M. Irfan, J. M. Kremsner, C. O. Kappe,
Chem. Eur. J. 2010, 16, 12182-1294.
194. Synthesis of 5-Substituted 1H-Tetrazoles from Nitriles and Hydrazoic Acid Using a Safe and Scalable High-Temperature Microreactor Approach.
B. Gutmann, J.-P. Roduit, D. Roberge, C. O. Kappe,
Angew. Chem. Int. Ed. 2010, 49, 7101-7105.
193. An Investigation of Wall Effects in Microwave-Assisted Ring-Closing Metathesis and Cyclotrimerization Reactions.
D. Dallinger, M. Irfan, A. Suljanovic, C. O. Kappe,
J. Org. Chem. 2010, 75, 5278–5288.
192. Electromagnetic Simulations of Microwave Heating Experiments Using Reaction Vessels Made out of Silicon Carbide.
J. Robinson, S. Kingman, D. Irvine, P. Licence, A. Smith, G. Dimitrakis, D. Obermayer, C. O. Kappe,
Phys. Chem. Chem. Phys. 2010, 12, 10793-10800.
191. Structural Basis for Inhibition of Eg5 by Dihydropyrimidines:
Stereoselectivity of Antimitotic Inhibitors Enastron, Dimethylenastron and
HPc45.
H. Y. K. Kaan, V. Ulaganathan, O. Rath, H.
Prokopcová, D. Dallinger, C. O. Kappe, F. Kozielski.
J. Med. Chem. 2010, 53, 5676–5683.
190. Diversity-Oriented Synthesis of Dibenzoazocines and Dibenzoazepines via a Microwave-Assisted Intramolecular A3-Coupling Reaction.
J. B. Bariwal, D. S. Ermolat’ev, T. N. Glasnov, K. Van Hecke, V. P. Mehta, L. Van Meervelt, C. O. Kappe, E. Van der Eycken,
Org. Lett. 2010, 13, 2774–2777.
189. Understanding Microwave Heating Effects in Single Mode Type Cavities – Theory and Experiment.
J. Robinson, S. Kingman, D. Irvine, P. Licence, A. Smith, G. Dimitrakis, D. Obermayer, C. O. Kappe,
Phys. Chem. Chem. Phys. 2010, 12, 4750-4758.
188. Direct Solid-Phase Synthesis of the β-Amyloid (1-42) Peptide Using Controlled Microwave Heating.
B. Bacsa, S. Bősze, C. O. Kappe
J. Org. Chem. 2010, 75, 2103-2106.
187. Mechanistic Insights Into Copper(I)-Catalyzed Azide-Alkyne Cycloadditions Using Continuous Flow Conditions.
M. Fuchs, W. Goessler, C. Pilger, C. O. Kappe
Adv. Synth. Catal. 2010, 352, 323-328.
186. Synthesis of Poly(ε-caprolactone) Diols and and EO-CL Block Copolymers and their Characterization by Liquid Chromatography and MALDI-TOF-MS.
H. Ahmed, B. Trathnigg, C. O. Kappe, R. Saf,
Eur. Pol. J. 2010, 46, 494-505.
185. Translating High-Temperature Microwave Chemistry to Scalable Continuous Flow Processes.
M. Damm, T. N. Glasnov, C. O. Kappe,
Org. Process Res. Develop. 2010, 14, 215-224.
184. Microwave-assisted High-throughput Derivatization Techniques Utilizing Silicon Carbide Microtiter Platforms
M. Damm, G. Rechberger, M. Kollroser, C. O. Kappe,
J. Chromat. A. 2010, 1217, 167-170.
183. Microwave-Assisted Synthesis of 5-Arylazo-4,6-disubstituted-3-cyano-2-pyridone Dyes.
D. Z. Mijin, M. Baghbanzadeh, C. Reidlinger, C. O. Kappe
Dyes Pigments 2010, 85, 73-78.
182. On the Importance of Simultaneous Infrared/Fiber-Optic Temperature Monitoring in the Microwave-Assisted Synthesis of Ionic Liquids.
D. Obermayer, C. O. Kappe
Org. Biomol. Chem. 2010, 8, 114-121.
2009
181. Microwave Chemistry in Silicon Carbide Reaction Vials: Separating Thermal from Nonthermal Effects.
D. Obermayer, B. Gutmann, C. O. Kappe
Angew. Chem. Int. Ed. 2009, 48, 8321-8342.
180. High-Speed Microwave-Assisted Synthesis of the Trifluoromethylpyrazol-derived Canonical Transient Receptor Potential Channel (TRPC3) Inhibitor Pyr3.
T. N. Glasnov, K. Groschner, C. O. Kappe
ChemMedChem 2009, 4, 1816-1818.
179. Microwave-Assisted Cross-Coupling and Hydrogenation Chemistry Using Heterogeneous Transition-Metal Catalysts: An Evaluation of the Role of Selective Catalyst Heating.
M. Irfan, M. Fuchs, T. N. Glasnov, C. O. Kappe
Chem. Eur. J. 2009, 15, 11608-11618.
178. Accessing Novel Process Windows in a High-Temperature/Pressure Capillary Flow Reactor.
T. Razzaq, T. N. Glasnov, C. O. Kappe,
Chem. Eng. Technol. 2009, 32, 1702-1716.
177. Kinetic Resolution of rac-1-Phenylethanol Using Immobilized Lipases – A Critical Comparison of Microwave and Conventional Heating Protocols.
R. O. M. A. de Souza, O. A. C. Antunes, W. Kroutil, C. O. Kappe,
J. Org. Chem. 2009, 74, 6157-6162.
176. Characterization of Poly(ethylene glycol)-b-poly(epsilon-caprolactone) by Liquid Chromatography under Critical Conditions: Influence of Catalysts and Reaction Conditions on Product Composition
H. Ahmed, B. Trathnigg, C. O. Kappe, R. Saf,
Eur. Pol. J. 2009, 45, 2338-2347.
175. An Evaluation of Microwave-Assisted Derivatization Procedures Using Hyphenated Mass Spectrometric Techniques.
M. Damm, G. Rechberger, M. Kollroser, C. O. Kappe,
J. Chromat. A. 2009, 1216, 5875-5881.
174. Palladium(0)-Catalyzed, Copper(I)-Mediated Coupling of Cyclic Thioamides with Alkenylboronic Acids, Organostannanes and Siloxanes.
N. Arshad, J. Hashim. C. O. Kappe
J. Org. Chem. 2009, 74, 5118-5121.
173. Parallel Microwave Chemistry in Silicon Carbide Reactor Platforms: An In-Depth Investigation Into Heating Characteristics.
M. Damm, C. O. Kappe,
Mol. Diversity 2009, 13, 529-543.
172. One-Pot Multicomponent Preparation of Tetrahydropyrazoloquinolinones and Tetrahydropyrazoloquinazolinones.
T. N. Glasnov, C. O. Kappe,
Org. Synth. 2009, 86, 252-261.
171. Parallel Microwave Synthesis of 2-Styrylquinazolin-4(3H)-ones in a High-Throughput Platform Using HPLC/GC Vials as Reaction Vessels.
M. Baghbanzadeh, M. Molnar, M. Damm, C. Reidlinger, M. Dabiri, C. O. Kappe,
J. Comb. Chem. 2009, 11, 676-684.
170. Bisquinolones as Chiral Fluorophores – A Combined
Experimental and Computational Study of Absorption and
Emission Characteristics
G. Uray, A.-M. Kelterer, J. Hashim, T. N. Glasnov, C. O. Kappe, W. M. F. Fabian,
J. Mol. Struct. 2009, 929, 85-96.
169. Microwave-Assisted Aliphatic Fluorine–Chlorine Exchange Using Triethylamine Trihydrofluoride (TREAT–HF).
J. M. Kremsner, M. Rack, C. Pilger, C. O. Kappe,
Tetrahedron Lett. 2009, 50, 3665-3668.
168. High-Throughput Experimentation Platform: Parallel Microwave Chemistry in HPLC/GC Vials.
M. Damm, C. O. Kappe,
J. Comb. Chem. 2009, 11, 460-468.
167. Microwave-Assisted Polymerizations of Higher Alkylene Oxides.
M. I. Malik, B. Trathnigg, C. O. Kappe
Eur. Pol. J. 2009, 45, 899-910.
166. Can Molecular Sieves Be Used as Water Scavengers in Microwave Chemistry?
M. Baghbanzadeh, C. O. Kappe
Austr. J. Chem. 2009, 62, 244-249.
165. Continuous Flow Hydrogenation of Functionalized Pyridines.
M. Irfan, E. Petricci, T. N. Glasnov, M. Taddei, C. O. Kappe
Eur. J. Org. Chem. 2009, 1326-1334.
164. Continuous Flow Microreactor Chemistry Under High Temperature/Pressure Conditions.
T. Razzaq, T. N. Glasnov, C. O. Kappe
Eur. J. Org. Chem. 2009, 1321-1325.
163. Heterogeneous Versus Homogeneous Palladium Catalysts for Ligandless Mizoroki-Heck Reactions. A Comparison of Batch/Microwave and Continuous Flow Processing.
T. N. Glasnov, S. Findenig, C. O. Kappe
Chem. Eur. J. 2009, 15, 1001-1015.
162. Microwave-Assisted Carbonyl Chemistry for the Undergraduate Laboratory.
S. S. Murphree, C. O. Kappe
J. Chem. Educ. 2009, 86, 227-229.
161. Amphiphilic Polymers Based on Higher Alkylene Oxides:
Synthesis and Characterization
by Different Chromatographic Techniques.
M. I. Malik, B. Trathnigg, C. O. Kappe
J. Chromat. A. 2009, 1216, 1167-1173.
2008
160. Multicomponent Cyclocondensation Reactions of Aminoazoles, Arylpyruvic Acids and Aldehydes with Controlled Chemoselectivity
Y. I. Sakhno, S. M. Desenko, S. V. Shishkina, O. V. Shishkin, D. O. Sysoyev, U. Groth, C. O. Kappe, V. A. Chebanov
Tetrahedron 2008, 64, 11041-11049.
159. Solid-Phase Synthesis of Difficult Peptide Sequences at Elevated Temperatures – A Critical Comparison of Microwave and Conventional Heating Technologies.
B. Bacsa, K. Horváti, S. Bősze, F. Andreae, C. O. Kappe
J. Org. Chem. 2008, 73, 7532-7542.
158. Investigating the Existence of Nonthermal/Specific Microwave Effects Using Silicon Carbide Heating Elements as Power Modulators.
T. Razzaq, J. M. Kremsner, C. O. Kappe
J. Org. Chem. 2008, 73, 6321-6329.
157. Microwave-Assisted One-Pot Diboration/Suzuki Cross-Couplings. A Rapid Route to Tetrasubstitued Alkenes.
H. Prokopcova, J. Ramírez, E. Fernández, C. O. Kappe,
Tetrahedron Lett. 2008, 49, 4831-4835.
156. Tuning of Chemo- and Regioselectivities in Multicomponent
Condensations of 5-Aminopyrazoles, Dimedone and Aldehydes
V. Chebanov, V. Saraev, S. Desenko, V. Chernenko, I. Knyazeva, U. Groth, T. Glasnov, C. O. Kappe
J. Org. Chem. 2008, 73, 5110-5118.
155. Synthesis of Bisquinolone-Based Mono- and Diphosphine Ligands of the Aza-BINAP Type
N. Arshad, J. Hashim. C. O. Kappe
J. Org. Chem. 2008, 73, 4755-4758.
154. Tetra-t-butyl-trioxabicyclo[3.3.1]nonadiene-dicarboxylic acid: Optical Resolution, Absolute Configuration and Application in Chiral Discrimination
J. M. Kremsner, B. C.Wallfisch, F. Belaj, G. Uray, C. O. Kappe, C. Wentrup, G. Kollenz
Eur. J. Org. Chem. 2008, 3382-3388.
153. Palladium(0) Nanoparticles on Glass-Polymer Composite Materials as Recyclable Catalysts: A Comparison Study on Their Use in Batch and Continuous Flow Processes
K. Mennecke, R. Cecilia, T. N. Glasnov, S. Gruhl, C. Vogt, A. Feldhoff, M. A. L. Vargas, C. O. Kappe, U. Kunz, A. Kirschning
Adv. Synth. Catal. 2008, 350, 717-730.
152. Integration of High Speed Microwave Chemistry and a Statistical “Design of Experiment” Approach for the Synthesis of the Mitotic Kinesin Eg5 Inhibitor Monastrol
T. N. Glasnov, H. Tye, C. O. Kappe
Tetrahedron 2008, 64, 2035-2041.
151. Microwave-Assisted Catalyst-Free Transesterification of Triglycerides with 1-Butanol under Supercritical Conditions
J. Geuens, J. M. Kremsner, B. A. Nebel, S. Schober, R. A. Dommisse, M. Mittelbach, S. Tavernier, C. O. Kappe, B. U. W. Maes
Energy Fuels 2008, 22, 643-645.
150. On the Enery Efficiency of Microwave-Assisted Organic Reactions
T. Razzaq, C. O. Kappe
ChemSusChem 2008, 1, 123-132.
149. Microwave-Assisted Synthesis and Characterization of End-Functionalized Poly(propylene oxide) as Model Compounds
M. I. Malik, B. Trathnigg, C. O. Kappe
Eur. Pol. J. 2008, 44, 144-154.
148. Nonthermal Microwave Effects Revisited – On the Importance of Internal Temperature Monitoring and Agitation in Microwave Chemistry
M. A. Herrero, J. M. Kremsner, C. O. Kappe
J. Org. Chem. 2008, 73, 36-47.
2007
147. Electrooxidation of Biginelli Dihydropyrimidones.
J. M. Aceves, R. Miranda, C. O. Kappe
ECS Transactions 2007, 3(32) 41-55.
146. Microwave-Assisted Click Chemistry for the Preparation of 3- and 4-Triazolyl-2(1H)-quinolones as Potential Fluorescent Probes
T. N. Glasnov, C. O. Kappe,
QSAR Comb. Sci. 2007, 26, 1261-1265.
145. Selectivity of EO-PO Diblock Copolymers in the Microwave-assisted Anionic Ring-Opening Polymerization of Propylene Oxide with PEG as Initiator.
M. I. Malik, B. Trathnigg, C. O. Kappe
Macromol. Chem. Phys. 2007, 208, 2510-2524.
144. Multicomponent Cyclocondensations of ß-Ketosulfones with Aldehydes and Aminoazole Building Blocks.
E. S. Gladkov, V. A. Chebanov, S. M. Desenko, O. V. Shishkin, S. V. Shishkina, D. Dallinger, C. O. Kappe
Heterocycles 2007, 73, 469-480.
143. Synthesis of Symmetrical Bisquinolones via Nickel(0)-Catalyzed Homocoupling of 4-Chloroquinolones .
J. Hashim, C. O. Kappe,
Adv. Synth. Catal. 2007, 349, 2353-2360.
142. Microwave Accelerated Aza-Claisen Rearrangements.
J. Gonda, M. Martinková, A. Zadrošová,
M. Šoteková, J. Raschmanová, P. Čonka, E. Gajdošíková, C. O. Kappe,
Tetrahedron Lett. 2007, 48, 6912-6915.
141. Rapid Solid-Phase Synthesis of a Calmodulin-Binding Peptide Using Controlled Microwave Irradiation
B. Bacsa, C. O. Kappe,
Nat. Protoc. 2007, 2, 2222-2227.
140. Microwave-Assisted Arylation of rac-(E)-3-Acetoxy-1,3-diphenylprop-1-ene with Arylboronic acids.
V. Poláčková, Š. Toma, C. O. Kappe,
Tetrahedron 2007, 63, 8742-8745.
139. An Algorithm for the Deconvolution of Mass Spectrosopic Patterns in Isotope Labeling Studies. Evaluation for the Hydrogen-Deuterium Exchange Reaction in Ketones.
C. C. Gruber, G. Oberdorfer, C. V. Voss, J. M. Kremsner, C. O. Kappe, W. Kroutil,
J. Org. Chem. 2007, 72, 5778-5783.
138. Microwave-Assisted Selective 5´-O-Trityl Protection of Inosine Derivatives.
E. Casanova, M.-J. Pérez-Pérez, C. O. Kappe,
Synlett 2007, 1733-1735.
137. Automated Generation of a Dihydropyrimidine Compound Library Using Microwave-Assisted Processing
D. Dallinger, C. O. Kappe,
Nat. Protoc. 2007, 2, 1713-1721.
136. Palladium(0)-Catalyzed, Copper(I)-Mediated Coupling of Boronic Acids with Cyclic Thioamides. Selective Carbon-Carbon Bond Formation for the Functionalization of Heterocycles.
H. Prokopcova, C. O. Kappe,
J. Org. Chem. 2007, 72, 4440-4448.
135. Parallel Synthesis of an Amide Library Based on the 6,8-Dioxa-3-azabicyclo[3.2.1]octane Scaffold by Direct Aminolysis of Methyl Esters.
F. Machetti, I. Bucelli, G. Indiani, C. O. Kappe, A. Guarna,
J. Comb. Chem. 2007, 9, 454-461.
134. 5-Aroyl-3,4-dihydropyrimidin-2-one Library Generation via Automated Sequential and Parallel Microwave-assisted Synthesis Techniques.
L. Pisani, H. Prokopcova, J. M. Kremsner, C. O. Kappe,
J. Comb. Chem. 2007, 9, 415-421.
133. One-Pot, Multicomponent Route to Pyrazoloquinolizines.
V. A. Chebanov, V. E. Saraev, S. M. Desenko, V. N. Chernenko, S. V. Shishkina, O. V. Shishkin, K. M. Kobzar, C. O. Kappe,
Org. Lett. 2007, 10, 1691-1694.
132. Rapid Preparation of Pyranoquinolines using Microwave Dielectric Heating in Combination with Fractional Product Distillation.
T. Razzaq, C. O. Kappe,
Tetrahedron Lett. 2007, 48, 2513-2517.
131. High-Throughput Microwave-Assisted Organic Synthesis - Moving from Automated Sequential to Parallel Library Generation Formats in Silicon Carbide Microtiter Plates.
J. M. Kremsner, A. Stadler, C. O. Kappe,
J. Comb. Chem. 2007, 9, 285-291.
130. Microwave-Assisted Solution- and Solid-Phase Synthesis of 2-Amino-4-arylpyrimidine Derivatives.
M. Matloobi, C. O. Kappe,
J. Comb. Chem. 2007, 9, 275-284.
129. Rapid Preparation of the Mitotic Kinesin Eg5 Inhibitor Monastrol Using Controlled Microwave-Assisted Synthesis.
D. Dallinger, C. O. Kappe,
Nat. Protoc. 2007, 2, 317-321.
128.Microwave-Assisted Asymmetric Organocatalysis. A Probe for Non-Thermal Microwave Effects and the Concept of Simultaneous Cooling.
M. Hosseini, N. Stiasni, V. Barbieri, C. O. Kappe,
J. Org. Chem. 2007, 72, 1417-1424.
127. Desulfitative Carbon–Carbon Cross-Coupling of Thioamide Fragments with Boronic Acids.
H. Prokopcova, C. O. Kappe,
Adv. Synth. Catal. 2007, 349, 448-452.
126. Cyclocondensation Reactions of 5-Aminopyrazoles, Pyruvic Acids and Aldehydes. Multicomponent Approaches to Pyrazolopyridines and Related Products.
V. A. Chebanov, Y. I. Sakhno, S. M. Desenko, V. N. Chernenko, V. I. Musatov, S. V. Shishkina, O. V. Shishkin, C. O. Kappe,
Tetrahedron 2007, 63, 1229-1242.
125. Synthesis of 5-Aroyl-dihydropyrimidinones via Liebeskind-Srogl Thiol Ester-Boronic Acid Cross Couplings.
H. Prokopcova, L. Pisani, C. O. Kappe,
Synlett 2007, 43-46.
2006
124. Rapid Solid-Phase Peptide
Synthesis using Thermal and Controlled Microwave Irradiation.
B. Bacsa, B. Desai, G. Dibo, C. O. Kappe,
J. Pept. Sci. 2006, 12, 633-638.
123. Silicon Carbide Passive
Heating Elements in Microwave-Assisted Organic Synthesis.
J. M. Kremsner, C. O. Kappe,
J. Org. Chem. 2006, 71, 4651-4658.
122. Microwave-Assisted Three-Component
Synthesis of 7-Aryl-2-alkylthio-4,7-dihydro-1,2,4-triazolo[1,5-a]-pyrimidine-6-carboxamides
and Their Selective Reduction.
V. A. Chebanov, E. A. Muravyova, S. M. Desenko, V. I. Musatov,
I. V. Knyazeva, S. V. Shishkina, O. V. Shishkin, C. O. Kappe,
J. Comb. Chem. 2006, 8, 427-434.
121. Microwave-Assisted Dimroth
Rearrangement of Thiazines to Dihydropyrimidinethiones: Synthetic and Mechanistic
Aspects.
T. N. Glasnov, D. J. Vugts, M. M. Koningstein, B. Desai, W. M. F. Fabian,
R. V. A. Orru, C. O. Kappe,
QSAR Comb. Sci. 2006, 25, 509-518.
120. Microwave-Assisted Solution
Phase Synthesis of Dihydropyrimidine C5 Amides and Esters.
B. Desai, D. Dallinger, C. O. Kappe,
Tetrahedron 2006, 62, 4651-4664.
119. Symmetrical Bisquinolones
via Metal-Catalyzed Cross-Coupling and Homocoupling Reactions.
J. Hashim, T. N. Glasnov, J. M. Kremsner, C. O. Kappe,
J. Org. Chem. 2006, 71, 1707-1710.
2005
118. Heterogeneous Hydrogenation
Reactions Using a Continuous Flow High Pressure Device.
B. Desai, C. O. Kappe,
J. Comb. Chem. 2005, 7, 641-643.
117. Monolithic Polymer/Carrier
Materials: Versatile Composites for Fine Chemical Synthesis.
U. Kunz, A. Kirschning, H.-L. Wen, W. Solodenko, R. Cecilia, C. O.
Kappe, T. Turek,
Catal. Today 2005, 105, 318-324.
116. Microwave-Assisted Organic
Synthesis in Near-Critical Water at 300 °C. A Proof-of-Concept Study.
J. M. Kremsner, C. O. Kappe,
Eur. J. Org. Chem. 2005, 3672-3679.
115. Porphyrins in Diels-Alder
Reactions. Improvements on the Synthesis of Barrelene-fused Chlorins using
Microwave Irradiation.
A. M. G. Silva, A. C. Tomé, M. G. P. M. S. Neves, J. A. S. Cavaleiro,
C. O. Kappe,
Tetrahedron Lett. 2005, 46, 4723-4726.
114. Novel Microwave-Enhanced
and Metal-Catalyzed Functionalizations of the 4-Aryl-Dihydropyrimidone
Template.
J. Wannberg, D. Dallinger, C. O. Kappe, M. Larhed,
J. Comb. Chem. 2005, 7, 574-583.
113. The Application of “Click
Chemistry” for the decoration of the 2(1H)-Pyrazinone Scaffold:
Generation of New Interesting Templates.
N. Kaval, D. Ermolat’ev, P. Appukkuttan, W. Dehaen, C. O. Kappe, E.
Van der Eycken,
J. Comb. Chem. 2005, 7, 490-502.
112. Microwave-Assisted Multistep
Synthesis of Functionalized 4-Arylquinolin-2(1H)-ones using Palladium-Catalyzed
Cross-Coupling Chemistry.
T. N. Glasnov, W. Stadlbauer, C. O. Kappe,
J. Org. Chem. 2005, 70, 3864-3870.
111. Selective
Polymer-Assisted Product Sequestration for the Generation of Combinatorial
Libraries of 1,3-Thiazines.
G. A. Strohmeier, C. Reidlinger, C. O. Kappe,
QSAR Comb. Sci. 2005, 24, 364-377.
2004
110. Combining
Biginelli Multicomponent and Click Chemistry: Generation of 6-(1,2,3-Triazol-1-yl)-Dihydropyrimidone
Libraries.
B. Khanetskyy, D. Dallinger, C. O. Kappe,
J. Comb. Chem. 2004, 6, 884-892.
109. Stereoconservative
Negishi Arylation and Alkynylation as an Efficient Approach to Enantiopure
2,2’-Diarylated 1,1’-Binaphthyls.
K. Krascsenicsováa, P. Walla, P. Kasáka, G. Uray, C.
O. Kappe, M. Putala,
Chem. Commun. 2004, 2606-2607.
108. A Diversity-Oriented,
Microwave-Assisted Synthesis of 4-oxo and 4-chloropyrido[2,3-d]pyrimidin-7(8H)-ones.
N. Mont, L. Fernández-Megido, J. Teixidó, C. O. Kappe
, J. I. Borrell,
QSAR Comb. Sci. 2004, 23, 836-849.
107. Synthesis
of Functionalized 1,3-Thiazine Libraries Combining Solid-Phase Synthesis
and Post-Cleavage Modification Methods.
G. A. Strohmeier, W. Haas, C. O. Kappe,
Chem. Eur. J. 2004, 10, 2919-2926.
106. Rapid
Microwave-Assisted Solution Phase Synthesis of Substituted 2-Pyridone Libraries.
N. Yu. Gorobets, B. H. Yousefi, F. Belaj, C. O. Kappe,
Tetrahedron 2004, 60, 8633-8644.
105. 2,6,9-Trioxabicyclo[3.3.1]nona-3,7-dien-4-oyl
and Tetraoxaadamantan-9-oyl Functionalized Aromatic Di- and Triamines:
Synthesis, Stereochemistry and Complexation.
W. Heilmayer, R. Smounig, K. Gruber, W. M. F. Fabian, C. Reidlinger,
C. O. Kappe, C. Wentrup, G. Kollenz,
Tetrahedron 2004, 60, 2857-2867
104. Tunable
Carbon-Carbon and Carbon-Sulfur Cross-Coupling of Boronic Acids with 3,4-Dihydropyrimidine-2-thiones.
A. Lengar, C. O. Kappe,
Org. Lett. 2004, 6, 771-774.
103. Microwave-Assisted
Negishi and Kumada Cross-Coupling Reactions of Aryl Chlorides.
P. Walla, C. O. Kappe,
Chem. Commun. 2004, 564-565.
102. Combinatorial
Synthesis of Functionalized 1,3-Thiazine Libraries Using a Combined Polymer-Supported
Reagent/Catch-and-Release Strategy.
G. A. Strohmeier, C. O. Kappe,
Angew. Chem. Int. Ed. 2004, 43, 621-624.
101. The
effect of pressure on microwave-enhanced Diels–Alder reactions. A case
study.
N. Kaval , W. Dehaen , C. O. Kappe, E. Van der Eycken,
Org. Biomol. Chem. 2004, 2, 154-156
100. Novel
Macrocyclic Systems containing 2,6,9-Trioxabicyclo[3.3.1]nona-3,7-dienes
as Chiral Spacer Groups : Synthesis, Stereochemical Features and Preliminary
Complexation Properties.
V. A.Chebanov, C. Reidlinger, H. Kanaani, C. Wentrup, C. O. Kappe,
G. Kollenz,
Supramol. Chem. 2004, 16, 121-127.
2003
99. Microwave-Assisted Scavenging
of Electrophiles Utilizing Polymer-Supported Sequestration Reagents. Application
to the Synthesis of N3-Acylated Dihydropyrimidine Libraries.
D. Dallinger, N. Yu. Gorobets, C. O. Kappe,
Mol. Diversity 2003, 7, 229-245.
98. A One-Pot Microwave-Assisted
Synthesis of Pyrido[2,3-d]pyrimidines.
N. Mont, J. Teixidó, C. O. Kappe, J. I. Borrell,
Mol. Diversity 2003, 7, 153-159.
97. Microwave-Enhanced Transition
Metal-Catalyzed Decoration of 2(1H)-Pyrazinone Scaffolds.
N. Kaval, K. Bisztray, W. Dehaen, C. O. Kappe, E. Van der Eycken,
Mol. Diversity 2003, 7, 125-133.
96. Microwave-Assisted Ring-Closing
Metathesis Revisited. On the Question of the Non-Thermal Microwave Effect.
S. Garbacia, B. Desai, O. Lavastre, C. O. Kappe,
J. Org. Chem. 2003, 68, 9136-9139.
95. Scalability of Microwave-Assisted
Organic Synthesis. From Single-Mode to Multimode Parallel Batch Reactors.
A. Stadler, B. H. Yousefi, D. Dallinger, P. Walla, E. Van der Eycken,
N. Kaval, C. O. Kappe
Org. Process Res. Dev. 2003, 7, 707-716.
94. Synthesis and Host-Abilities
of some new Corands Bearing Uncommon Chiral Spacer Units.
W. Heilmayer, B. Wallfisch, C. O. Kappe, C. Wentrup, K. Gloe, G. Kollenz,
Supramol. Chem. 2003, 15, 375-383.
93. An Exploratory Study on
Microwave-Assisted Solid-Phase Diels-Alder Reactions of 2(1H)-Pyrazinones:
The Elaboration of a New Tailor-Made Acid-Labile Linker.
N. Kaval, J. Van der Eycken, J. Caroen, W. Dehaen, G. A. Strohmeier,
C. O. Kappe, E. Van der Eycken,
J. Comb. Chem. 2003, 5, 560-568.
92. A Three-Component Synthesis
of Pyrido[2,3-d]pyrimidines.
N. Mont, J. Teixidó, J. I. Borrell, C. O. Kappe,
Tetrahedron Lett. 2003, 44, 5385-5387.
91. Synthesis and Complexation
Properties of Some Novel Lariat-Crown Ethers.
R. Smounig, C. O. Kappe, C. Wentrup, G. Kollenz,
Monatsh. Chem. 2003, 134, 509-518.
90. Enantioseparation
of Racemic 4-Aryl-3,4-dihydro-2(1H)-pyrimidones on Chiral Stationary Phases
Based on 3,5-Dimethylanilides of N-(4-Alkylamino-3,5-dinitro)benzoyl L-a-Amino
Acids.
D. Kontrec, V. Vinkovic, V. Sunjic, B. Schuiki, W. M. F. Fabian, C.
O. Kappe,
Chirality 2003, 15, 550-557.
89. High-Throughput Synthesis
of N3-Acylated Dihydropyrimidines Combining Microwave-Assisted Synthesis
and Scavenging Techniques.
D. Dallinger, N. Yu. Gorobets, C. O. Kappe.
Org. Lett. 2003, 5, 1205-1208.
88. Rapid Preparation of
Thioamide Building Blocks via Microwave-Promoted Three-Component Kindler
Reactions.
O. I. Zbruyev, N. Stiasni, C. O. Kappe,
J. Comb. Chem. 2003, 5, 145-148.
2002
87. High-Speed Microwave-Promoted
Hetero-Diels-Alder Reactions of 2(1 H)-Pyrazinones in Ionic Liquid
Doped Solvents.
E. Van der Eycken, P. Appukkuttan, W. De Borggraeve, W. Dehaen, D.Dallinger,
C. O. Kappe,
J. Org. Chem. 2002, 67, 7904-7907.
86. Selective N 1-Alkylationof
3,4-Dihydropyrimidin-2(1H)-ones Using Mitsunobu-Type Conditions.
D. Dallinger, C. O. Kappe,
Synlett 2002, 1901-1903.
85. Rapid Formation of Triarylphosphines
by Microwave-Assisted Transition Metal-Catalyzed C-P Cross-Coupling Reactions.
A. Stadler, C. O. Kappe,
Org. Lett. 2002, 4, 3541-3543.
84. A Tandem Intramolecular
Michael-Addition/Elimination Sequence in Dihydropyrimidone to Quinoline
Rearrangements.
N. Stiasni, C. O. Kappe,
ARKIVOC 2002, (8), 71-79.
83. Traceless Solid Phase
Synthesis of Bicyclic Dihydropyrimidones Using Multidirectional Cyclization
Cleavage.
R. Pérez, T. Beryozkina, O. I. Zbruyev, W. Haas. C. O. Kappe,
J. Comb. Chem. 2002, 4, 501-510.
82. 2,6,9-Trioxabicyclo[3.3.1]nona-3,7-dienes
and 2,4,6,8-Tetraoxaadamantanes: Novel Chiral Spacer Units in
Macrocyclic Polyethers.
B. C. Wallfisch, T. Egger, W.Heilmayer, C. O. Kappe, C.Wentrup,
K. Gloe, F. Belaj, G. Klintschar, G. Kollenz,
Supramol. Chem. 2002, 14, 383-396.
81. Microwave-Assisted Reactions
under Open and Closed Vessel Conditions. A Case Study.
A. Stadler, S. Pichler, G. Horeis, C. O. Kappe,
Tetrahedron 2002, 58, 3177-3183.
80. Synthesis and Chemical
Reactivity of Methoxycarbonyl-1,3-dioxinyl-pivaloyketene; a Persistent a-Oxoketene.
B. C. Wallfisch, F. Belaj, C. O. Kappe, G. Kollenz,
J. Chem. Soc., Perkin Trans. 1 2002, 599-605.
79. Rapid Parallel Synthesis
of Polymer-Bound Enones Utilizing Microwave-Assisted Solid-Phase Chemistry.
G. A. Strohmeier, C. O. Kappe,
J. Comb. Chem. 2002, 4, 154-161.
2001
78. Automated Library Generation
Using Sequential Microwave-Assisted Chemistry. Application Toward the Biginelli
Multicomponent Condensation.
A. Stadler, C. O. Kappe,
J. Comb. Chem. 2001, 3, 624-630.
77. Absolute Configuration
in 4-Alkyl- and 4-Aryl-3,4-dihydro-2(1H)-pyrimidones: A Combined Theoretical
and Experimental Investigation.
G. Uray, P. Verdino, F. Belaj, C. O. Kappe, W. M. F. Fabian,
J. Org. Chem. 2001, 66, 6685-6694.
76. Fluorocontaining 1,3-Dicarbonyl
Compounds in the Synthesis of Pyrimidine Derivatives.
Y. V. Burgart, O. G. Kuzueva, M. V. Pryadeina, C. O. Kappe, Y. I. Saloutin,
Russ. J. Org. Chem. 2001, 37, 869-880.
75. On the Reaction of 3,4-Dihydropyrimidones
with Nitric Acid. Preparation and X-Ray Structure Analysis of a Stable
Nitrolic Acid.
A. Puchala, F. Belaj, J. Bergman, C. O. Kappe,
J. Heterocyclic Chem. 2001, 38, 1345-1352.
74. Reactions of Dipivaloylketene
and its Dimer with NH2 Nucleophiles. Formation of Amides, Hydrazides,
Ureides and Pyrimidine-2,4-diones.
G. Kollenz, C. O. Kappe, T.S. Dalvi, C. Wentrup,
ARKIVOC, 2001, 2, 30-41.
73. High-Speed Microwave-Promoted
Mitsunobu Inversions. Application to the Deracemization of Sulcatol.
A. Steinreiber, A. Stadler, S. F. Mayer, K. Faber, C. O. Kappe,
Tetrahedron Lett., 2001, 42, 6283-6286.
72. Chiral Separation of Pharmacologically
Active Dihydropyrimidinones with Carboxymethyl-ß-cyclodextrin.
O. Lecnik, M. G. Schmid, C. O. Kappe, G. Gübitz,
Electrophoresis, 2001, 22, 3198-3202.
71. Solid-Phase Synthesis
of Dihydropyrimidones via N-Acyliminium Ion-Based a-Ureidoalkylations.
M. G. Valverde, D. Dallinger, C. O. Kappe,
Synlett, 2001, 741-744.
70. The Biginelli Dihydropyrimidone
Synthesis Using Polyphosphate Ester as a Mild and Efficient Cyclocondensation/Dehydration
Reagent.
F. S. Falsone, C. O. Kappe,
ARKIVOC, 2001, 2, 1234-1249.
69. The Effect of Microwave
Irradiation on Carbodiimide-Mediated Esterifications on Solid-Support.
A. Stadler, C. O. Kappe,
Tetrahedron, 2001, 57, 3915-3920.
68. Iminopropadienethiones,
Ar-N=C=C=C=S.
C. O. Kappe, D. Kvaskoff, D. W. J. Moloney, R. Flammang, C. Wentrup,
J. Org. Chem. 2001, 66, 1827-1831.
67. Preparation and Chemistry
of an Unexpectedly Stable a-Oxoketene-Pyridine
Zwitterion, Di-t-butylcarbonyl-(4-dimethylamino)pyridinium Methylidene
Olate.
G. Kollenz, S. Holzer, C. O. Kappe, T. S. Dalvi, W. M. F. Fabian, H.Sterk,
M. W. Wong, C. Wentrup,
Eur. J. Org. Chem., 2001, 1315-1322.
66. High-Speed Couplings and
Cleavages in Microwave-Heated, Solid-Phase Reactions at High Temperatures.
A. Stadler, C. O. Kappe,
Eur. J. Org. Chem. 2001, 919-925.
65. Microwave-Mediated Regioselective
Synthesis of Novel Pyrimido[1,2-a]pyrimidines under Solvent-free Conditions.
J. J. Vanden Eynde, N. Hecq, O. Kataeva, C. O. Kappe,
Tetrahedron, 2001, 57, 1785-1791.
2000
64. Chemoenzymatic Syntheses
of Enantiomerically Pure 4-Aryl-3,4-Dihydropyrimidin-2(1H)-Ones.
B. Schnell, W. Krenn, K. Faber, C. O. Kappe,
J. Chem. Soc., Perkin Trans. 1, 2000, 4382-4389.
63. The Rhodium(II)-Catalyzed
Equilibration of Push-Pull Carbonyl and Ammonium Ylides. A Computationally-
Based Understanding of the Reaction Pathway.
A. Padwa, J. P. Snyder, E. A. Curtis, S. M. Sheehan, K. J. Worsencroft,C.
O. Kappe,
J. Am. Chem. Soc. 2000, 122, 8155-8167.
62. Microwave-Mediated Biginelli
Reactions Revisited. On the Nature of Rate and Yield Enhancements.
A. Stadler, C. O. Kappe,
J. Chem. Soc., Perkin Trans. 2, 2000, 1363-1368.
61. Design and Synthesis of
a ConformationallyRigid Mimic of the Dihydropyrimidine Calcium Channel
Modulator SQ32,926.
B. Jauk, T. Pernat, C. O. Kappe,
Molecules, 2000, 5, 227-239.
60. Synthesis of Enantiomerically
Pure 4-Aryl-3,4-dihydropyrimidin-2(1H)-ones via Enzymatic Resolution. Preparation
of the Antihypertensive Agent (R)-SQ32926.
B. Schnell, U. T. Strauss, P. Verdino, K. Faber, C. O. Kappe,
Tetrahedron: Asymmetry, 2000, 11, 1449-1453.
59. X-Ray Structure, Conformational
Analysis, Enantioseparation, and Determination of Absolute Configuration
of the Mitotic Kinesin Eg5Inhibitor Monastrol.
C. O. Kappe, O. V. Shishkin, G. Uray, P. Verdino,
Tetrahedron, 2000, 56, 1859-1862.
58. Reactions of Dipivaloylketene
and its Dimer with C-Nucleophiles.
G. Kollenz, T. S. Dalvi, C. O. Kappe, C. Wentrup,
ARKIVOC 2000, 1, 84-89.
57. Biginelli Condensations
of Fluorinated 3-OxoEsters and 1,3-Diketones.
V. I. Saloutin, Ya. V. Burgart, O. G. Kuzueva, C. O. Kappe, O. N. Chupakhin,
J. Fluorine Chem., 2000, 103, 17-23.
56. Ab Initio and Density
Functional Calculations on the Pericyclic versus Pseudopericyclic Mode
of Conjugated Nitril Ylide 1,5-Electrocyclizations.
W. M. F. Fabian, C. O. Kappe, V. A. Bakulev,
J. Org. Chem., 2000, 65, 47-53.
55. Highly Versatile Solid
Phase Synthesis of Biofunctional 4-Aryl-3,4 dihydropyrimidines using Polymer-Bound
Isothiourea BuildingBlocks and Multidirectional Resin Cleavage.
C. O. Kappe,
Bioorg. Med. Chem. Lett., 2000, 10, 49-51.
1999
54. Microwave-Assisted High-Speed
Parallel Synthesis of 4-Aryl-3,4-dihydropyrimidin-2(1H)-ones using a Solventless
BiginelliCondensation Protocol.
C. O. Kappe, D. Kumar, R. S. Varma,
Synthesis, 1999, 1799-1803.
53. Determination of Absolute
Configuration in4-Aryl-3,4-dihydro-2(1H)-pyrimidones by High Performance
Liquid Chromatographyand CD Spectroscopy.
W. Krenn, P. Verdino, G. Uray, K. Faber, C. O. Kappe,
Chirality, 1999, 11, 659-662.
52. A Rhodium-Induced Cyclization-Cycloaddition
Sequence for the Construction of Conformationally Rigid Calcium ChannelModulators
of the Dihydropyrimidine Type.
B. Jauk, F. Belaj, C. O. Kappe,
J. Chem. Soc., Perkin Trans. 1, 1999, 307-314.
51. Isolation, Conformational
Analysis and X-RayStructure Determination of a Trifluoromethyl-Stabilized
Hexahydropyrimidine- An Intermediate in the Biginelli Reaction.
C. O. Kappe, S. F. Falsone, W. M. F. Fabian, F. Belaj,
Heterocycles, 1999, 51, 77-84.
1998
50. Pericyclic Versus Pseudopericyclic
1,5-Electrocyclization of Iminodiazomethanes. An Ab Initio and Density
Functional Theory Study.
W. M. F. Fabian, V. A. Bakulev, C. O. Kappe,
J. Org. Chem., 1998, 63, 5801-5805.
49. Synthesis and Reactions
of Biginelli Compounds, 12. Polyphosphate Ester-Mediated Synthesis of Dihydropyrimidines.
Improved Conditions for the Biginelli Reaction.
C. O. Kappe, S. F. Falsone,
Synlett, 1998, 718-720.
48. On the Reaction of Dipivaloylketene
Dimer with Oximes and Hydrazines - Synthesis of Tetraoxaadamantanes.
T. S. Dalvi, C. O. Kappe, C. Wentup, G. Kollenz,
Heterocycles, 1998, 48, 1841-1850.
47. Synthesis and Reactions
of Biginelli Compounds, 11. Ring Conformation and Ester Orientation in
Dihydropyrimidinecarboxylates: A Combined Theoretical (Ab Initio, Density
Functional) and X-Ray Crystallographic Study. W. M. F. Fabian, M. A. Semones,
C. O. Kappe,
J. Mol. Struct. (Theochem), 1998, 432, 219-229.
46. Carboxy(vinyl)ketene Intermediates
in the Thermolysis of Methylthio- and Methoxy-Substituted Meldrum's Acid
Derivatives.
H. Bibas, C. O. Kappe, M. W. Wong, C. Wentrup,
J. Chem. Soc., Perkin Trans. 2, 1998, 493-498.
45. A Triple Cascade Sequence
as a Strategy for the Construction of the Erythrina Skeleton.
A. Padwa, R. Hennig, C. O. Kappe, T. S. Reger,
J. Org. Chem., 1998, 63, 1144-1155.
1997
44. Synthesis and Reactions of
Biginelli Compunds, 9. A Reexamination of the Mechanism of the Biginelli
Dihydropyrimidine Synthesis. Support for an N-Acyliminium Ion Intermediate.
C. O. Kappe,
J. Org. Chem., 1997, 62, 7201-7204.
43. Synthesis and Reactions
of Biginelli Compunds, 10. Synthesis and Aromatization of Dihydropyrimidines
Structurally related to Calcium Channel Modulators of the Nifedipine-Type.
J. J. Vanden Eynde, N. Audiart, V. Canonne, S. Michel, Y. Van Haverbeke,
C. O. Kappe
Heterocycles, 1997, 45, 1967-1978.
42. Synthesis and Reactions
of Biginelli Compunds, 8. Separation of Enantiomers of 4-Aryldihydropyrimidines
by Direct Enantioselective HPLC. A Critical Comparison of Chiral Stationary
Phases.
O. P. Kleidernigg, C. O. Kappe,
Tetrahedron: Asymmetry, 1997, 8, 2057-2067.
41. Ammonium Ylide Versus
Carbonyl Ylide Formation in the Rhodium(II)-Catalyzed Decomposition of
Diazoacetylureas. Generation and X-Ray Structure of a Stable Five-Membered
N-Acyl Ammonium Ylide.
C. O. Kappe,
Tetrahedron Lett., 1997, 38, 3323-3326.
40. Synthesis and Reactions
of Biginelli Compounds, 7. Dipolar Cycloaddition Reactions of Dihydropyrimidine-Fused
Mesomeric Betaines. An Approach Towards Conformationally Restricted Dihydropyrimidine
Derivatives.
C. O. Kappe, K. Peters, E.-M. Peters,
J. Org. Chem., 1997, 62, 3109-3118.
39. Studies Dealing with the
Cycloaddition/Ring Opening/Elimination Sequence of 2-Amino-Substituted
Isobenzofurans
A. Padwa, C. O. Kappe, J. E Cochran, J. P. Snyder,
J. Org. Chem., 1997, 62, 2786-2797.
38. Synthesis and Reactions
of Biginelli Compounds, 6. Conformational Analysis of 4-Aryl-Dihydropyrimidine
Calcium Channel Modulators. A Comparison of Ab Initio, Semiempirical and
X-Ray Crystallographic Studies.
C. O. Kappe, W. M. F. Fabian, M. A. Semones,
Tetrahedron, 1997, 53, 2803-2816.
1996
37. A Facile and Efficient Synthesis
of Thieno[2,3-c]furans and Furo[3,4-b]indoles Via a Pummerer Induced Cyclization
Reaction.
C. O. Kappe, A. Padwa,
J. Org. Chem., 1996, 61, 6166-6174.
36. Tandem Diels-Alder N-Acyliminium
Ion Cyclization Reactions. A New Entry into the Erythrinane Skeleton.
A. Padwa, C. O. Kappe, T. S. Reger,
J. Org. Chem., 1996, 61, 4888-4889.
35. The Tandem Pummerer Diels-Alder
Reaction Sequence. A Novel Cascade Process for the Preparation of 1-Arylnaphthalene
Lignans.
A. Padwa, J. E. Cochran, C. O. Kappe,
J. Org. Chem., 1996, 61, 3706-3714.
1995
34. Generation and Subsequent
Cycloaddition Chemistry of alpha-Amino Isobenzofurans Formed by Cationic
Cyclization.
C. O. Kappe, J. E. Cochran, A. Padwa,
Tetrahedron Lett., 1995, 36, 9285-9288.
33. A Convenient De Novo
Synthesis of Functionalized 2,4,6,8-Tetraoxaadamantanes.
W. Heilmayer, T. S. Dalvi, C. O. Kappe, C. Wentrup, K. Gruber, H. Sterk,
G. Kollenz,
J. Chem. Soc., Chem. Commun., 1995, 797-798.
32. Acetylketene: Conformational
Isomerism and Photochemistry. Matrix Isolation Infrared and Ab Initio Studies.
C. O. Kappe, M. W. Wong, C. Wentrup,
J. Org. Chem., 1995, 60, 1686-1695.
31. Substituent Effects on
the Site of Nucleophilic Attack in Pyrrole-2,3-diones.
C. O. Kappe, E. Terpetschnig, G. Penn, G. Kollenz, K. Peters, E.-M.
Peters, H. G. von Schnering,
Liebigs Ann. Chem., 1995, 537-543.
1994
30. An Improved Synthesis of
5-Alkyl-2,3-dihydrofuran-2,3-diones.
C. O. Kappe, G. Kollenz, C. Wentrup,
Heterocycles, 1994, 38, 779-784.
29. Synthesis and Flash Vacuum
Pyrolysis of Isoxazolo- and Isothiazolo[5,4-d]pyrimidines.
C. O. Kappe, R. Flammang, C. Wentrup,
Heterocycles, 1994, 37, 1615-1622.
28. Iminoethenethiones, RN=C=C=S:
Characterization by Neutralization-Reionization Mass Spectrometry and G2(MP2)
Theory.
R. Flammang, D. Landu, S. Laurent, M. Barbieux-Flammang, C. O. Kappe,
M. W. Wong, C. Wentrup,
J. Am. Chem. Soc., 1994,116, 2005-2015.
27. Conformation and Reactivity
of alpha-Oxo Ketenes: Ab Initio and Semiempirical (AM1, PM3) Calculations.
R. Janoschek, W. M. F. Fabian, G. Kollenz, C. O. Kappe,
J. Comput. Chem., 1994, 15, 132-143.
26. Thioacylthioketenes by
Pyrolysis of 1,3-Dithiethanes and 1,2-Dithiole Derivatives.
C. O. Kappe, C. T. Pedersen, J.-M. Catel, Y. Mollier,
J. Chem. Soc., Perkin Trans. 2, 1994, 351-355.
25. The Formation of Thioacylthioketenes
by Flash Vacuum Pyrolysis of 1,2-Dithiole Derivatives.
C. T. Pedersen, C. O. Kappe,
Phosphorus, Sulfur Silicon Relat. Elem. 1994, 95-96,
485-486.
1993
24. [2+4] Cycloaddition Reactions
of Neat Dipivaloylketene.
C. O. Kappe, C. Wentrup, G. Kollenz,
Monatsh. Chem., 1993, 124, 1331-1341.
23. Matrix Isolation and
Infrared Spectrum of Thioformyl Cyanide.
C. O. Kappe, M. W. Wong, C. Wentrup,
Tetrahedron Lett., 1993, 34, 6623-6626.
22. On the Thermal Fragmentation
of 3-Methyl-1-phenylpyrazole-4,5-dione.
C. O. Kappe, G. Kollenz, C. Wentrup,
Acta Chem. Scand., 1993, 47, 940-942.
21. Direct Observation and
Trapping of a Heterocyclic alpha-Oxo Ketene: 3-Carbonyl-1,3-dihydro-1-
methyl-2-indol-2-one.
C. O. Kappe, G. Färber, C. Wentrup, T. Kappe,
Chem. Ber., 1993, 126, 2357-2360.
20. On the Reaction of 4-Benzoyl-5-phenylfuran-2,3-dione
with S-Heterocumulenes - Preparative and Mechanistic Aspects.
W. Heilmayer, C. O. Kappe, H. Sterk, G. Kollenz, K. Peters, E.-M. Peters,
H.-G. von Schnering, L. Walz,
Chem. Ber., 1993, 126, 2061-2067.
19. Reactions of Dipivaloylketene-Dimer
with Nucleophiles: New Access to the 2,6,9-Trioxabicyclo[3.3.1]nona-3,7-diene
Ring System (Bridged Bis-Dioxines).
C. O. Kappe, G. Kollenz, W. M. F. Fabian, C. Wentrup, G. Färber,
J. Org. Chem., 1993, 58, 3361-3367.
1992
18. Dipivaloylketene and Its
Dimers. [2+4] Versus [2+2] Cycloaddition Reactions of alpha-Oxo Ketenes.
C. O. Kappe, G. Färber, C. Wentrup, G. Kollenz,
J. Org. Chem., 1992, 57, 7078-7083.
17. A Novel and Convenient
Approach to Functionalized 2,6,9-Trioxabicyclo[3.3.1]nona-3,7-dienes (Bridged
Bis-Dioxines).
C. O. Kappe, G. Färber, C. Wentrup, G. Kollenz,
Tetrahedron Lett., 1992, 33, 4553-4556.
16. Synthesis and Reactions
of Biginelli Compounds, 5. Facile Preparation and Resolution of a Stable
5-Dihydropyrimidinecarboxylic Acid.
C. O. Kappe, G. Uray, P. Roschger, W. Lindner, C. Kratky, W. Keller,
Tetrahedron, 1992, 48, 5473-5480.
15. Direct Observations of
Benzoylketenes.
Yu. S. Andreichikov, G. Kollenz, C. O. Kappe, R. Leung-Toung, C. Wentrup,
Acta Chem. Scand., 1992, 46, 683-685.
14. Iminopropadienones,
RN=C=C=C=O: Syntheses and Reactions.
T. Mosandl, C. O. Kappe, R. Flammang, C. Wentrup,
J. Chem. Soc., Chem. Commun., 1992, 1571-1573.
13. Imidoylketene-Azetin-2-one-Oxoketenimine
Rearrangement.
C. O. Kappe, G. Kollenz, K.-P. Netsch, R. Leung-Toung, C. Wentrup,
J. Chem. Soc., Chem. Commun., 1992, 488-490.
12. Methyleneketene-Imidoylketene-Oxoketenimine
Rearrangements.
C. O. Kappe, G. Kollenz, R. Leung-Toung, C. Wentrup,
J. Chem. Soc., Chem. Commun., 1992, 487-488.
11. A Nitroketene to Nitrile
Oxide Transformation.
C. O. Kappe, G. Kollenz, C. Wentrup,
J. Chem. Soc., Chem. Commun., 1992, 485-486.
1991
10. Dipivaloylketene and Its
Unusual Dimerization to a Permanently Stable alpha-Oxoketene.
C. O. Kappe, R. A. Evans, C. H. L. Kennard, C. Wentrup,
J. Am. Chem. Soc., 1991, 113, 4234-4237.
9. Cross-Conjugated and Pseudo-Cross-Conjugated
Mesomeric Betaines, 18. Bicyclic Mesoionic Pyrimidines with Cardiovascular
Activity.
C. O. Kappe, T. Kappe,
Arch. Pharm., 1991, 324, 863-866.
8. Thermolysis and Photolysis
of 6-Diazidomethyl-1,2,3,4-tetrahydro-2-oxopyrimidine-5-carboxylates (Synthesis
and Reactions of Biginelli Compounds, 4).
C. O. Kappe, G. Färber,
J. Chem. Soc., Perkin Trans. 1, 1991, 1342-1344.
7. On the Reaction of 2,2,6,6,-Tetramethyl-3,5-heptanedione
("Dipivaloylmethane") with Oxalyl Chloride.
G. Kollenz, C. O. Kappe, H. Abd el Nabey,
Heterocycles, 1991, 32, 669-673.
1990
6. Synthesis and Reactions of
Biginelli Compounds, 3. Unexpected Formation of Nitriles from Reactions
of 6-(Dibromomethyl)-1,2,3,4-tetrahydro2-oxo-5-pyrimidinecarboxylates with
Sodium Azide.
C. O. Kappe,
Liebigs Ann. Chem., 1990, 505-507
1989
5. Quinolizines and Indolizines,
16. Synthesis of Pyrrolo[3,2,1-ij]quinolin-4-ones with Potential Fungicidal
Activity.
C. O. Kappe, T. Kappe,
J. Heterocycl. Chem., 1989, 26, 1555-1560.
4. Synthesis of Substituted
3-Pyridinecarbonitriles with Potential Biological Activity.
C. O. Kappe, T. Kappe,
Monatsh. Chem., 1989, 120, 1095-1100.
3. Synthesis and Reactions
of Biginelli Compounds, 2. Nitration of 6-Methyl-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylates.
C. O. Kappe, U. G. Wagner,
Heterocycles, 1989, 29, 761-769.
2. Synthesis and Reactions
of Biginelli Compounds, 1.
C. O. Kappe, P. Roschger,
J. Heterocycl. Chem., 1989, 26, 55-64.
1988
1. A Convenient Synthesis of Functionalized 1H-Pyrimidine-2-thiones.
Y. Akcamur, B. Altural, E. Saripinar, G. Kollenz, C. O. Kappe, K. Peters,
E.-M. Peters, H.-G. von Schnering,
J. Heterocycl. Chem., 1988, 25, 1419-1422.
Color Code: Full Paper/ Note / Communication
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