Judith S. Fabjan, MSc, PhD  Institute of Pharmacology and Toxicology  Karl-Franzens University of Graz Universitätsplatz 2 8010 Graz, Austria Tel.: (++43 +316) 380 5500 Fax.: (++43 +316) 380 98 57 Judith.Fabjan@kfunigraz.ac.at

* both authors have equally contributed to this work
• Feichtenhofer S, Fabjan JS and Abuja PM.

Ceruloplasmin as low-density lipoprotein oxidase: Activation by ascorbate and dehydroascorbate.
FEBS 501:42-46, 2001.
 
• Fabjan JS, Abuja PM, Schaur RJ, Sevanian A.

Hypochlorite induces the formation of LDL-, a potentially atherogenic low density lipoprotein subspecies.
FEBS 499:69-72, 2001.
 
• Fabjan JS, Karlovska J, Abuja PM, Hammel M, Balgavy P, Schaur RJ.

Kinetics of the inhibition of sarcoplasmic Ca/Mg ATPase by hypochlorite.
Submitted
 
• Egger G, Burda A, Obernosterer H, Mitterhammer G, Kager G, Jürgens, G, Hofer HP, Fabjan JS, Pilger E.

Blood polymorphonuclear leucocyte activation in atherosclerosis: Effects of aspirin.
Inflammation 25(2):199-208, 2001.
 
• Jerlich A*, Tschabuschnig S*, Fabjan JS, Schaur RJ.

Kinetics of chlorination of monochlorodimedone by myeloperoxidase.
Int J Clin Lab Res 30:33-37, 2000.
 
• Jerlich A*, Horakova L*, Fabjan JS, Giessauf A, Jürgens G, Schaur RJ.

Correlation of low density lipoprotein modification by myeloperoxidase with hypochlorous acid formation.
Int J Clin Lab Res 29:155-161, 1999.
 
• Byun J*, Mueller DM*, Fabjan JS, Heinecke JW.

Nitrogen dioxide radical generated by the myeloperoxidase-hydrogen peroxide-nitrite system promotes lipid peroxidation of low density lipoprotein.
FEBS 455:243-246, 1999.
 
• Jerlich A, Fabjan JS, Tschabuschnig S, Smirnova AV, Horakova L, Hayn M, Auer H, Guttenberger H, Leis H-J,Tatzber F, Waeg G, Schaur RJ.

Human low density lipoprotein as a target of hypochlorite generated by myeloperoxidase.
Free Radic Biol Med 24:1139-1148, 1998.
 
• Egger G, Kukovetz EM, Hayn M, Fabjan JS.

Changes in polymorphonuclear leucocyte function of blood samples induced by storage time, temperature and agitation.
J Immunol Meth 206:61-71, 1997.

* presenting author / ° oral presentation
• Jerlich A*, Fabjan JS, Tschabuschnig S, Smirnova AV, Horakova L, Hayn M, Haslinger E, Guttenberger H, Schaur RJ.

Apo B-100 of LDL as target of myeloperoxidase generated HOCl.
FASEB J 11:3369-3369, 1997.
Abstract 3369 from the 17. International Congress of Biochemistry and Molecular Biology, San Francisco, USA. 24.-29. August 1997.
 
• Jerlich A*, Fabjan JS, Tschabuschnig S, Smirnova AV, Horakova L, Hayn M, Haslinger E, Guttenberger H, Schaur RJ.

Apo B-100 of LDL is modified by myeloperoxidase-generated HOCl.
Atherosclerosis 134:223-223, 1997.
Abstract 3.P.120, from the XI. International Symposium on Atherosclerosis, Paris, France, 5.-9. October 1997
 
• Fabjan JS*, Jerlich A, Horakova L, Tschabuschnig S, Guttenberger H, Schaur RJ.

Modification of apo B-100 of LDL by human myeloperoxidase.
Atherosclerosis 134:221-221, 1997.
Abstract 3.P.110 from the "XI. International Symposium on Atherosclerosis", Paris, France, 5.-9. October 1997.
 
• Schaur RJ, Jerlich A*, Fabjan JS, Tschabuschnig S, Hayn M, Gießauf A, Horakova L.

Limitations for the modifying activity of human myeloperoxidase towards low density lipoprotein.
Eur J Haematol, Suppl 59, 57:6, 1996.
Abstract AP 19 from the "2. International Congress on Phagocytes, Biological and Clinical Aspects", Pavia, Italy. 4.-7. September 1996.

Other Meeting Participations

* presenting author / ° oral presentation
• Jerlich A, Fabjan JS, Schaur RJ°*.

Modification of human LDL by the myeloperoxidase/hydrogen peroxide/chloride system
"The Peroxidase Superfamily II of Animal and Human Enzymes: Biochemical and Clinical Application", Vienna, Austria, 03.-08 September 2000. Abstract Volume "Oral Presentation 12".
 
• Fabjan JS*, Jerlich A, Tschabuschnig S, Ziouzenkova O, Hayn M, Schaur RJ.

Myeloperoxidase and its impact on the atherogenic properties of low density lipoprotein: Lipid peroxidation versus protein modification.
Workshop Hypochlorous Acid as Metabolite of Neutrophilic Granulocytes. Leipzig, Germany, 5.-6. March 1998. Abstract-Volume P-2.
 
• Fabjan JS*, Ziouzenkova O, Tschabuschnig S, Jerlich A, Hayn M, Schaur RJ.

Myeloperoxidase-dependent lipid peroxidation of low density lipoprotein.
Satellite Symposium of the XI. International Symposium on Atherosclerosis - Abbaye de Royaumont, France: Atherogenic LDL - Pathophysiology and New Therapeutic Approaches, 2.-4. October 1997. Abstract-Volume p. P4.
 
• Jerlich A*, Horakova L, Gießauf A, Fabjan JS, Schaur RJ.

Self-limitations for the modifying activity of myeloperoxidase towards LDL.
Satellite Symposium of the XI. International Symposium on Atherosclerosis - Abbaye de Royaumont, France: Atherogenic LDL - Pathophysiology and New Therapeutic Approaches, 2.-4. October 1997. Abstract-Volume p. P8.
 
• Schaur RJ°*, Horakova L, Jerlich A, Fabjan JS.

Basic studies on the mechanism of action of a hydrogen pump inhibitor in the treatment of gastrointestinal disorders.
Symposium - Recent advances in the mechanism of drug action, Castle of Smolenice, Slovakia. 16.-17. September 1997.

Oral Presentations

• Fabjan JS°*, Jerlich A, Tschabuschnig S, Schaur RJ.

Immunological studies of myeloperoxidase-modified human low density lipoprotein.
I. Sympózium s medzinárodnou úcast'ou o ateroskleróze a dyslipoproteinémiách. Bratislava, Slovak Republic, 12.-14. October 1997. Abstract p. 12, Ateroskleróza Vol. 3, 1997.

Invited Lectures

• Fabjan JS

Myeloperoxidase: Primary Intermediates and Secondary Products.
Part of the graduate students lecture: Lipidperoxidation by Dr. P.M. Abuja. Institute of Biochemistry, Graz, Austria, June 1999
 
• Fabjan JS

Role of Myeloperoxidase and its Reactive Products in Atherogenesis.
Ludwig-Bolzmann Institute of Anaesthesiology and Traumatology, Vienna, Austria, 15. May 2000.

Curriculum Vitae

September 1986 - September 1996

Study at the University of Graz (Biology/Zoology)

 

March 1993 - June 1993

Research at the Institute of Medical Biochemistry on "Development of quantitative methods for the determination of apoD".

 

October 1993 - October 1994

Research at the Institute of Medical Biochemistry on "Basic characterisation of serum lipoproteins of LPL (lipoprotein lipase) overexpressing mice".

 

May 1995 - July 1996

Diploma thesis at the Institute of Molecular Biology, Biochemistry and Microbiology (former Institute of Biochemistry), University of Graz on "Modifications of low density lipoprotein by myeloperoxidase: An immunological approach".

 

March 1997

Diploma exam, Master in Zoology (specialty in metabolic physiology, immunology and lipoprotein chemistry).

 

since May 1997

Doctoral dissertation at the Institute of Molecular Biology, Biochemistry and Microbiology (former Institute of Biochemistry), University of Graz on modifications of lipoproteins and proteoliposomes by human myeloperoxidase - Implications for atherosclerosis".

May 1997 - June 1997

Research at the Department of Physical Chemistry, Comenius University, Bratislava, Slovakia on "Application of a coupled enzyme system to measure the impact of HOCl on the activity of isolated Ca/Mg ATPase and Ca/Mg ATPase proteoliposomes".

 

January and February 1998

Short-time project funded by the Austrian-Slovak Society at the Department of Physical Chemistry, Comenius University, Bratislava, Slovakia on the "Development of a method for the determination of MPO-mediated effects on Ca/Mg ATPase reconstituted in phospholipid liposomes".

 

April 1998 - June 1998

Research at the Department of Molecular Pharmacology and Toxicology, University of Southern California, CA, USA on "Formation of potentially atherogenic, minimally oxidized subspecies of LDL (LDLminus) by HOCl".

 

June and July 1998

Research at the Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA on "Promotion of lipid peroxidation of LDL by nitrogen dioxide radical generated by the MPO/hydrogen peroxide/nitrite system".

 

September 1999 - December 1999

Short-time project funded by a Wood-Whelan stipendium (IUBMB) at the Department of Molecular Pharmacology and Toxicology, University of Southern California, CA, USA on "Atherogenic alteration of LDL by HOCl: Lipid peroxidation versus protein modification".

 

Major fields of training

UV spectroscopy, liquid chromatography, immunological methods, analysis of lipoproteins

 

Research experience

Oxidative modification of human plasma lipoproteins; antibody isolation, purification and characterisation.

 

Current status

Post doctoral fellow