Karl-Franzens-Universität Graz

Weis, Robert, Ao.Univ.-Prof. Mag.pharm. Dr.rer.nat.

Building: Stremayrgasse 16/II
A-8010 Graz / Austria

Sprechstunde: Mittwoch 10:00 – 10:15 Uhr

Tel: +43-316-380-5379
Fax: +43-316-380-9846

Email: Robert.Weis@uni-graz.at

weis

Curriculum:

1988

1990

1993

2003

Mag. pharm.

Univ.-Ass.

Dr. rer. nat.

Univ.-Doz., ao. Univ.-Prof.

Teaching:

Lectures:

Arzneistoffsynthese
Arzneistoffkombinationen und – Spezialitäten
Synthetische Arzneistoffe
Arzneistoffe: Syntheseplanung und Strukturbeweis

Apparative Methoden der Strukturaufklärung
Strukturaufklärung neuer Wirkstoffe gegen Tropenkrankheiten I
Strukturaufklärung neuer Wirkstoffe gegen Tropenkrankheiten II

Pharmazeutische Chemie (II)
Neue Forschungsergebnisse in Pharmazeutischer Chemie
Spezielle Arbeitstechniken in Pharmazeutischer Chemie

Laboratory courses:

Übungen aus Arzneistoffsynthese
Vertiefte Übungen aus Pharmazeutischer Chemie

Research projects:

Synthesis and structural elucidation of compounds with anti-infective activity

Selected Publications:

54.	Berger, Heinrich; Seebacher, Werner; Kaiser, Marcel; Brun, Reto; Saf, Robert; Weis, Robert: *SARs of the antiprotozoal action of 6,7-diaryl-bicyclo[2.2.2]octan-2-ols,* Monatshefte fuer Chemie: an international journal of chemistry 140 (2009), 495 - 502.
53.	Faist, Johanna; Seebacher, Werner; Schlapper, Christian; Kaiser, Marcel; Brun, Reto; Saf, Robert; Weis, Robert: *Antiplasmodial and antitrypanosomal activity of bicyclic amides and esters of dialkylamino acids,* Bioorganic & Medicinal Chemistry 17 (2009), 3595 - 3603.
52.	Schlapper, Christian; Seebacher, Werner; Faist, Johanna; Kaiser, Marcel; Brun, Reto; Saf, Robert; Weis, Robert: *Antiplasmodial and antitrypanosomal activity of aminobicyclo[2.2.2]octyl omega-amino-aminoalkanoates,* European Journal of Medicinal Chemistry 44,2 (2009), 736 - 744.
51.	Weis, Robert; Seebacher, Werner: *New bicyclic amines: Synthesis and SARs of their action against the causative organisms of Malaria and sleeping sickness,* Current Medicinal Chemistry 16 (2009), 1426 - 1441.
50.	Berger, Heinrich; Weis, Robert; Kaiser, Marcel; Brun, Reto; Saf, Robert; Seebacher, Werner: Novel Azabicyclo[3.2.2]nonane derivatives and their activities against Plasmodium falciparum K1 and Trypanosoma b. rhodesiense, Bioorganic & Medicinal Chemistry 16 (2008), 6371 - 6378.
49.	Schlapper, Christian; Seebacher, Werner; Kaiser, Marcel; Reto, Brun; Saf, Robert; Weis, Robert: *Epimers of bicyclo[2.2.2]otan-2-ols with antiprotozoal activity.,* European Journal of Medicinal Chemistry 43 (2008), 800 - 807.
48.	Weis, Robert; Berger, Heinrich; Kaiser, Marcel; Brun, Reto; Saf, Robert; Seebacher, Werner: *Synthesis of bicyclic amines and their activities against Trypanosoma brucei rhodesiense and Plasmodium falciparum K1,* Archives of Pharmacal Research 31,6 (2008), 688 - 697.
47.	Weis, Robert; Faist, Johanna; Di Vora, Ulrike; Schweiger, Klaus; Brandner, Barbara; Kungl, Andreas; Seebacher, Werner: *Antimycobacterial Activity of Diphenylpyraline Derivatives, European Journal of Medicinal* European Journal of Medicinal Chemistry 43 (2008), 872 - 879.
46.	Weis, Robert; Kaiser, Marcel; Brun, Reto; Saf, Robert; Seebacher, Werner: *Acyl Derivatives of 5-Amino-2-azabicyclo[3.2.2]nonanes,* Monatshefte fuer Chemie: an international journal of chemistry 139 (2008), 717 - 724.
45.	Weis, Robert; Schweiger, Klaus; Faist, Johanna; Rajkovic, Erich; Kungl, Andreas; Fabian, Walter; Schunack, Walter; Seebacher, Werner: *Antimycobacterial and H1-antihistaminic activity of 2-substituted piperidine derivatives,* Bioorganic & Medicinal Chemistry 16 (2008), 10326 - 10331.
44.	Schlapper, Christian; Seebacher, Werner; Kaiser, Marcel; Reto, Brun; Saf, Robert; Weis, Robert: *Bicyclo[2.2.2]octyl esters of dialkylamino acids as antiprotozoals,* Bioorganic & Medicinal Chemistry 15 (2007), 5543 - 5550.
43.	Seebacher, Werner; Kaiser, Marcel; Reto, Brun; Saf, Robert; Weis, Robert: *Antiprotozoal Activities of epimeric Aminobicycles,* Monatshefte fuer Chemie: an international journal of chemistry 138 (2007), 709 - 714.
42.	Seebacher, Werner; Weis, Robert; Saf, Robert; Kaiser, Marcel; Reto, Brun: *New 4-Amino-2-azabicyclo[3.2.2]nonane derivatives and their Antiprotozoal Potencies,* Monatshefte fuer Chemie: an international journal of chemistry 138 (2007), 619 - 625.
41.	Berger, Heinrich; Seebacher, Werner; Saf, Robert; Kaiser, Marcel; Brun, Reto; Weis, Robert: *Antiprotozoal activities of new bis-chlorophenyl derivatives of bicyclic octanes and aza-nonanes,* Bioorganic & Medicinal Chemistry Letters 16 (2006), 5457 - 5461.
40.	Seebacher, Werner; Berger, Heinrich; Kaiser, Marcel; Brun, Reto; Saf, Robert; Weis, Robert: *Structural Requirements for the Antiprotozoal Activity of 4-Aminobicyclo[2.2.2]octan-2-ols,* Monatshefte fuer Chemie: an international journal of chemistry 137 (2006), 471 - 482.
39.	Seebacher, Werner; Saf, Robert; Brun, Reto; Kaiser, Marcel; Weis, Robert: *Isomerization of 4-amino-6,7-diphenylbicyclo[2.2.2]octan-2-ones,* Canadian Journal of Chemistry 84 (2006), 1074 - 1078.
38.	Seebacher, Werner; Schlapper, Christian; Brun, Reto; Kaiser, Marcel; Saf, Robert; Weis, Robert: *Synthesis of new esters and oximes with 4-aminobicyclo[2.2.2]octane structure and evaluation of their antitrypanosomal and antiplasmodial activities,* European Journal of Medicinal Chemistry 41 (2006), 970 - 977.
37.	Weis, Robert; Kaiser, Marcel; Brun, Reto; Saf, Robert; Seebacher, Werner: *Hydrazones and new Oximes of 4-Aminobicyclo[2.2.2]octanones and their Antiprotozoal Activities,* Monatshefte fuer Chemie: an international journal of chemistry 137 (2006), 1365 - 1374.
36.	Weis, Robert; Schlapper, Christian; Brun, Reto; Kaiser, Marcel; Seebacher, Werner: *Antiplasmodial and antitrypanosomal activity of new esters and ethers of 4-dialkylaminobicyclo[2.2.2]octan-2-ols,* European Journal of Pharmaceutical Sciences 28 (2006), 361 - 368.
35.	Seebacher, Werner; Brun, Reto; Kaiser, Marcel; Saf, Robert; Weis, Robert: *Synthesis and evaluation of the antitrypanosomal and antiplasmodial activities of new 4-aminobicyclo[2.2.2]octane derivatives,* European Journal of Medicinal Chemistry 40 (2005), 888 - 896.
34.	Seebacher, Werner; Kaiser, Marcel; Brun, Reto; Saf, Robert; Weis, Robert: *4-Aminobicyclo[2.2.2]octan-2-ones and –ols via Enamine Intermediates,* Monatshefte fuer Chemie: an international journal of chemistry 136 (2005), 625 - 634.
33.	Seebacher, Werner; Kröpfl, Dietmar; Belaj, Ferdinand; Saf, Robert; Hüfner, Antje; Weis, Robert: *Investigations on the Formation of 4-Aminobicyclo[2.2.2]octanones,* Molecules: a journal of synthetic organic and natural product chemistry 10 (2005), 521 - 533.
32.	Seebacher, Werner; Schlapper, Christian; Brun, Reto; Kaiser, Marcel; Saf, Robert; Weis, Robert: *Antiprotozoal activities of new bicyclo[2.2.2.]octan-2-imines and esters of bicyclo[2.2.2.]octan-2-ols,* European Journal of Pharmaceutical Sciences 24 (2005), 281 - 289.
31.	Seebacher, Werner; Weis, Robert; Kaiser, Marcel; Brun, Reto; Saf, Robert: *Synthesis of 2-azabicyclo[3.2.2]nonanones from bicyclo[2.2.2]octan-2-ones and their activities against Trypanosoma brucei rhodesiense and Plasmodium falciparum K1,* Journal of Pharmacy and Pharmaceutical Sciences 8,3 (2005), 578 - 585.

List of publications 2004 - 1992

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Lectures at Conferences:

Seebacher, Werner; Schlapper, Christian; Berger, Heinrich; Weis, Robert:
Bicyclische Amine und ihre Wirkung gegen Protozoen,
PhaWi-Graz. Workshop des Instituts für Pharmazeutische Wissenschaften der Karl-Franzens-Universität Graz 21-22. 9. 2006
Schlapper, Christian; Berger, Heinrich; Seebacher, Werner; Weis, Robert:
4-Aminobicyclo[2.2.2]octanderivate mit verbesserter Wirkung gegen Protozoen,
19. Wissenschaftliche Tagung der Österreichischen Pharmazeutischen Gesellschaft, Innsbruck, 20.4. - 22.4.2006
Weis, Robert:
Synthese und antimykobakterielle Aktivität neuer Diphenylpyralin- und Bamipinderivate, Beitrag (Presenter),
17. Wissenschaftliche Tagung derÖsterreichischen Pharmazeutischen Gesellschaft, Graz, 24.4. - 26.4.2003, ÖPhG (Österreich), Graz, 25.04.2003.

Selected Poster:

Weis, Robert; Faist, Johanna; Seebacher, Werner:
Antitrypanosomal Activity of 4-Aminobicyclo[2.2.2]octane Derivatives,
ÖPHG-Tagung Wien, 16.4.-18.4.2009, 2009.
Weis, Robert; Faist, Johanna; Seebacher, Werner:
2-AZABICYCLO[3.2.1]NONANES WITH ANTITRYPANOSOMAL ACTIVITY,
Jahrestagung der DPHG 2007, Erlangen, 10.10. – 13.10.2007, 2007.
Weis, Robert; Faist, Johanna; Seebacher, Werner:
Antimykobakterielle Wirkung von 4-Alkoxypiperidinen,
19. Wissenschaftliche Tagung der Österreichischen Pharmazeutischen Gesellschaft, Innsbruck, 20.4. - 22.4.2006, 2006.

Further information see:

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Institute of Pharmaceutical Sciences - Institute Management