Development of methods for enantiomer separation by High Performance Liquid Chromatography (HPLC) and Capillary Electrophoresis (CE). This topic involves synthesis of new chiral selectors for HPLC , CE and the new principle of capillary electrochromatography (CEC); Synthesis of chiral phases, development of new chiral separation principles; application to the separation of the enantiomers of compounds of biological interest, drugs and pestizides. Development of Flow-Injection Immunoassays (FIIA). Flow-Injection Immunoassays represent a new, rapid immunoassay technique making use of Flow-Injection Analysis systems. Hetero-and homogeneous assays using fluorescence- and chemiluminescence detection are beeing developed. Application of these systems for pharmaceutical analysis, environmental analysis and diagnostic purposes are under investigation. The main interest of our research work is focussed on the development of methods for the determination of biological active compounds in the picomole or femtomole range in biological materials. This includes pharmacokinetic studies of drugs and metabolites in blood, plasma, serum and urine as well as pesticide quantification in water and other materials, analysis of cosmetic products, or prostaglandin and phospholipid determination in different human materials. In order to enhance sensitivity and selectivity derivatization agents for flourescence or electrochemical detetion in combination with chromatographic separation techniques are beeing designed. Photolytic processes and recently, problems dealing with clinical pharmacy are under investigation. Further projects are centered around modern analytics of pumpkin seeds and their oil as well as sterol analysis of eatable oils.
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